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Signaling Pathways Involved in Mechanical Stimulation and ECM Geometry in Bone Cells
Mechanical Stimulation Osteoblast ECM
2015/1/12
The proliferation and differentiation of osteoblasts are influenced by mechanical and geometrical growth environments. A specific aim of my thesis was the elucidation of signaling pathways involved in...
Functional Lateral Shift of the Mandible Effects on the Expression of ECM in Rat Temporomandibular Cartilage
Condylar cartilage Functional lateral shift of the mandible Extracellular matrix
2010/3/5
Objective: To test the hypothesis that the effects of mechanical stress from a functional lateral shift of the mandible have no effect on the expression of two main condylar cartilage extracellular ma...
非小细胞肺癌中整合素和ECM蛋白表达与转移及预后的相关性研究
整合素 细胞外基质 肺肿瘤 免疫组织化学
2013/12/10
肿瘤的浸润和转移严重威胁着人类生命，正确认识和评估肿瘤的生物学行为有重要的临床意义。整合素和细胞外基质（ECM）的异常表达在肿瘤浸润转移过程中发挥着重要作用。本研究的目的是探讨整合素α5、β1（integrin α5、β1）与细胞外基质（ECM）在人非小细胞肺癌（NSCLC）中的表达及其与淋巴结转移及患者预后之间的关系，评估它们在肿瘤转移过程的作用。方法 采用免疫组化方法测定119例NSCLC组...
通过对体外培养的肾小球系膜细胞和建立大鼠thy-1系膜增生性肾炎动物模型的 实验研究，观察了肝素对细胞增生及其细胞外基质(ECM)合成或沉积的抑制作用，并集中探讨其作用的分子机制，发现肝素的抑制作用可能与该细胞某些自分泌生长因子(血小板源性生长因子)生成的影响、细胞增殖相关癌基因(c-fos, c-jum, c-myc)和基质降解酶系统(PAI-1)的表达等机制密切有关。该课题还采用细胞转基因技术...
Airway Remodeling in Asthma and Irreversible Airflow Limitation—ECM Deposition in Airway and Possible Therapy for Remodeling—
bone marrow-derived cells CTGF myofibroblast peripheral airway TGF-β
2010/11/18
Airway remodeling in asthma is characterized by goblet cell hyperplasia, subepithelial fibrosis, and hyperplasia and hypertrophy of airway smooth muscle cells. The airway wall thickness increases beca...