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Repression of cyclin D1 as a target for germ cell tumors
metastatic germ cell tumors cyclin D1
2014/12/12
Metastatic germ cell tumors (GCT) are curable, however GCTs refractory to cisplatin-based chemotherapy have a poor prognosis. This study explores D-type cyclins as molecular targets in GCTs because al...
Assessment of Piwil2 Gene Expression Pattern upon Germ Cell Development from Mouse Embryonic Stem Cell
Embryonic stem cell Germ cell Embryoid body Piwil2
2015/9/18
Background: In order to improve culture conditions for optimal spermatogenesis, quantitative assessment of the male germ cell gene expression profile upon spontaneous ES cell differentiation is necess...
Germ cell degeneration in the contralateral testis of the guinea pig with unilateral torsion of the spermatic cord. Quantitative and ultrastructural studies
testis torsion quantitation germ cell guinea pig reproduction
2009/2/23
This study evaluated the long term effects of unilateral torsion of the spermatic cord on the contralateral testis of guinea pigs, employing both fine structural and quantitative studies. Young, adu...
Pure Sertoli Cell Cultures：A New Model for the Study of Somatic-Germ Cell Interactions
cell cultures Sertoli cell germ cell
2009/2/19
A new technique involving a brief hypotonic treatment was developed for obtaining pure rat Sertoli cell cultures. This method for the selective removal of the germ cells present in Sertoli cell enri...
Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
Brown Norway rat accelerated germ cell apoptosis luteinizing hormone replacement
2009/2/18
Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination ...
Contrin, the human homologue of a germ-cell Y-box-binding protein：cloning, expression, and chromosomal localization
human homologue germ-cell Y-box-binding protein chromosomal localization
2009/2/18
Inactivation of germ-cell-specific molecules essential for the production of functional spermatozoa could lead to attractive new means for male contraception. The mouse protein MSY2 is the mammali...
Hormonal regulation of spermatogenesis in the hypophysectomized rat: quantitation of germ-cell population and effect of elimination of residual testosterone after long-term hypophysectomy
Testis germ cells androgen morphometry
2009/2/17
Spermatogenesis continues after long-term hypophysectomy (Hx), but massive cell degeneration prevents seminiferous tubules from attaining the full complement of cells. One objective of this study ...
Interactions of proteases and protease inhibitors in Sertoli-germ cell cocultures preceding the formation of specialized Sertoli-germ cell junctions in vitro
proteases and protease inhibitors Sertoli-germ cell specialized Sertoli-germ cell
2009/2/17
The biochemical mechanism(s) by which germ cells can form specialized junctions with Sertoli cells in the seminiferous epithelium at various stages of the spermatogenic cycle is unknown. This stud...
Is Leydig cell steroidogenic function affected by the germ cell content of the seminiferous tubules?
Leydig cell steroidogenesis
2009/2/17
The effect of testicular germ cell content on Leydig cell steroidogenic function in vivo in adult rats was examined. Three experimental paradigms were used to effect germ cell changes. First, a vita...
Impaired germ cell development in the testes of immature rats with neonatal hypothyroidism
Gonocyte Sertoli cell thyroid hormone stereology optical disector germ cell number
2009/2/17
The induction of neonatal hypothyroidism from day 1 to day 25 postpartum using 6-propyl-2-thiouracil (PTU) resulted in a 45% and 77% reduction of testis weight on days 20 and 30, respectively, and a...
Early effects of vasectomy on testicular structure and on germ cell and macrophage apoptosis in the hamster
Male contraception vasectomy germ-cell apoptosis macrophage apoptosis testosterone testis
2009/2/17
This study provides quantitative information on the early (up to 3 months) effects of vasectomy on apoptosis in the hamster testis. Groups of five adult male golden hamsters were either bilaterall...
Heat stress causes testicular germ cell apoptosis in adult mice
Spermatogenesis testis cryptorchidism
2009/2/17
An investigation was undertaken to determine whether the germ-cell loss associated with exposure of the testis to abdominal temperature occurs by apoptosis. Using an adult-mouse model of experimenta...
Alternative splicing of CREB and CREM mRNAs in an immortalized germ cell line
CREB CREM alternative splicing testis immortalized germ cells germ cells
2009/2/17
Alternative splicing of CREB (cAMP response element binding protein) and CREM (cAMP response element modulator) mRNAs in separated pachytene spermatocyte, round spermatid, and elongated spermatid ...
Differential expression of clusterin in the testis and epididymis of postnatal and germ cell deficient mice
clusterin epididymis postnatal germ cell deficient mice
2009/2/16
Clusterin is found in a wide variety of tissues and is expressed in a number of physiological and pathological contexts. It is expressed constitutively in the adult male reproductive tract, specific...
Testicular composition, number of A spermatogonia, germ cell ratios, and number of spermatids in three different breeds of boars
Breed boar testis composition
2009/2/16
Seminal quality, including the number of spermatozoa in the ejaculate, varies among breeds of boars. Variation in seminal quality may be explained by breed differences in testicular size and compo...