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Researchers from Harvard’s Stem Cell and Regenerative Biology (HSCRB)’s Zon lab have discovered a new mechanism that influences melanoma development, a finding that could have wide implications for pa...
Too much, too little, just right. It might seem like a line from “Goldilocks and the Three Bears,” but actually describes an important finding from researchers in Florida Atlantic University’s College...
Malignant melanoma is one of the rare and highly aggressive diseases of the sinonasal cavity. High index of suspicion is required for diagnosis as the patient usually presents with non specific signs ...
Melanoma     Melanoma  natural history       2015/4/8
Forty years ago the causes, incidence and natural history of melanoma were still poorly understood. Little was known about prognostic factors, and radical surgery was routine for all melanomas. Howe...
This review discusses the relevant imaging techniques for both melanoma and non-melanoma skin cancers, including basal cell carcinomas, cutaneous squamous cell carcinomas and Merkel cell carcinomas....
The critical role of pathology in the multidisciplinary care of melanoma patients is becoming apparent in the rapidly changing modern era of personalised and precisely targeted medicine. Recent insi...
Metastatic melanoma has a poor prognosis and until recently systemic therapy was ineffective. Advances in the understanding of tumour biology and immune regulation have led to the development of tar...
Loco-regionally recurrent melanoma encompasses local recurrence (usually defined as being within 2cm of the primary tumour site), in-transit recurrence and regional lymph node recurrence. Survival i...
Much of the resistance of melanoma to immunotherapy, radiotherapy and cytotoxic treatment is due to an impressive array of molecular defences that derive ultimately from the essential molecular struct...
In the early 20th Century, excision of all primary melanomas with >5cm clearance margins was recommended, with amputation in selected cases – recommendations based on experience of a few patients with...
Non-melanoma skin cancers occur at an epidemic rate in Australia and are increasing in incidence worldwide. In most patients local treatment is curative. However, a subset of patients will be diagnos...
This edition of Cancer Forum reports a series of papers prepared for a Festschrift held in honour of Emeritus Professor William McCarthy AM at the Royal Prince Alfred Hospital on 29 July 2005. Profes...
Routine skin examination, either conducted by a doctor or by self-screening, is widely practised in Australia, although authoritative groups and clinical guidelines do not recommend screening. This i...
Two relatively new methods have changed the way primary melanoma is diagnosed. Dermoscopy (surface microscopy, epiluminescence microscopy) is a technique that was introduced at the beginning of the 1...
The surgical treatment of melanoma has been progressively rationalised during the last two decades. Radical excision of primary tumours and elective (prophylactic) resection of regional lymph nodes h...

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