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Background: The effect of a weight-loss intervention on the masses of lean tissues and organs in humans is not well known.Objective: We studied the effects of a diet and exercise weight-loss intervent...
Background: The association between the time of nutrient intake and health has been described in a few studies. To our knowledge, no study has evaluated the relation between high energy intakes at lun...
Background: The association between the time of nutrient intake and health has been described in a few studies. To our knowledge, no study has evaluated the relation between high energy intakes at lun...
Background: Sugar-sweetened beverage (SSB) consumption and low-grade chronic inflammation are both independently associated with type 2 diabetes and cardiovascular disease. Fructose, a major component...
Background: Sugar-sweetened beverage (SSB) consumption and low-grade chronic inflammation are both independently associated with type 2 diabetes and cardiovascular disease. Fructose, a major component...
The results of previous studies suggest that de novo lipogenesis may play an important role in the etiology of obesity, particularly during overconsumption of different carbohydrates.
Results of leptin administration in mice, rats, and humans provide a rationale for therapeutic augmentation of circulating leptin (OB protein) concentrations in obese humans; this may reduce food i...
Previous studies investigating the hypothesis that a low resting metabolic rate (RMR) is a cause of obesity yielded discrepant findings. Two explanations for these findings are the use of imprecise...
The results of previous studies indicated that energy density, independent of fat content, influences energy intake. In most studies, however, both fat content and energy density were lower than in...
In animals, the whole-body content and accumulation of linoleate can be measured and compared with its intake to determine linoleate -oxidation. This method can also provide quantitative informatio...
Energy restriction is known to induce a decline in fat oxidation during the postdiet period. Reduced fat oxidation may contribute to weight regain.
Alterations in glucose metabolism during early fasting may be an important trigger of the hormonal and metabolic responses to fasting.
Weight reduction reduces bone mineral density (BMD) and increases the risk of osteoporosis.
The influence of the amount and type of carbohydrates in the diet on risk factors for obesity, diabetes, and cardiovascular disease remains unclear.

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