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Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats
Diabetes mellitus erectile dysfunction anandamide cannabinoid system nitric oxide corpus cavernosum
2009/12/16
Background: It is well known that erectile dysfunction is most commonly associated with diabetes, affecting 35% to 75% of men with diabetes mellitus. Several studies have been carried out to find appr...
NADPH Diaphorase staining of the corpus cavernosum in cholestatic rats:Role of nitrergic and opioid systems
Cholestasis erection nitric oxide opioids naltrexone corpus cavernosum
2009/12/7
Background: Relaxation of the corpus cavernosum plays an important role in penile erection. Previous studies have suggested that nitric oxide (NO) appears to be the most important relaxant involved in...
Characterization of prostaglandin E receptor subtypes involved in the relaxation of rabbit penile corpus cavernosum smooth muscle
prostaglandin E receptor subtypes rabbit penile corpus cavernosum smooth muscle
2009/3/3
Prostaglandin E (PGE) induces the penile erection in the mammalians. Receptors for PGE were characterized to 4 different subtypes (EP1—4). The effects of agonists for EP1—4 receptors were studied on...
Evidence for a role of intracellular-calcium release in nitric oxide-stimulated relaxation of the rabbit corpus cavernosum
Calcium erection thapsigargin ryanodine
2009/2/17
Erection is mediated by relaxation of the smooth muscle elements within the sinusoids of the corpus cavernosum. Although cavernosal relaxation can be mediated by a variety of mechanisms including pu...
Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum
Penile erection testosterone adrenergic prazosin
2009/2/17
Rat penile erection is an androgen-dependent process with castration leading to a loss of potency. The present study was designed to determine if one of the mechanisms by which androgens maintain th...
Increased expression of a 68-kDa protein in the corpus cavernosum of some men with erectile dysfunction
Erectile dysfunction cavernous body gel electrophoresis structural proteins
2009/2/13
Erectile dysfunction (ED) may be caused by abnormalities of intracavernous penile structures. In order to investigate whether specific proteins could be identified that might be related to ED, the c...
Participation of vasoactive intestinal polypeptide（VIP）as a humoral mediator in the erectile response of canine corpus cavernosum penis
VIP neurotransmitter penile erection immunoneutralization
2009/2/12
The ability of anti-vasoactive intestinal peptide (anti-VIP) serum to suppress the electrically induced relaxation of the corpus cavernosum was evaluated in vitro to define the role of VIP in penile...
Metabolic studies on the rabbit corpus cavernosum
Metabolic studies rabbit corpus cavernosum
2009/2/12
Erectile function (erection and detumescence) involves the complex interaction of direct neuronal stimulation of corporal smooth muscle, neurohumoral release of specific endothelial contractile an...
Adipocyte Accumulation in Penile Corpus Cavernosum of the Orchiectomized Rabbit: A Potential Mechanism for Veno-occlusive Dysfunction in Androgen Deficiency
Trabecular smooth muscle veno-occlusion fat-containing cells
2008/12/23
Androgens are deemed to be critical for the development, growth, and maintenance of penile tissue as well as for erectile function. Androgens are also reported to inhibit differentiation of stroma p...
Corpus Cavernosum Smooth Muscle Physiology: A Role for Sex Hormones?
Corpus Cavernosum Smooth Muscle Physiology Role Sex Hormones
2008/12/19
The penis contains 3 long cylindrical tubes of tissue: the corpus spongiosum and dorsally a pair of corpus cavernosum (CC) (Figure 1A). The CC is contained within a tough outer covering known as t...
Cavernous Neurotomy Causes Hypoxia and Fibrosis in Rat Corpus Cavernosum
Erectile dysfunction radical prostatectomy neurapraxia
2008/12/19
The etiologies of erectile dysfunction (ED) after nerve-sparing radical prostatectomy have not been clearly elucidated. The aim of this study was to evaluate the effects of cavernous nerve injury on c...
The Kv2.2 Subunit Contributes to Delayed Rectifier K+ Currents in Myocytes From Rabbit Corpus Cavernosum
Penile erection potassium channels patch clamp techniques smooth muscle molecular cloning
2008/12/16
K+ currents are known to regulate the excitability of corpus cavernosum myocytes and therefore to play a role in the control of penile erection and detumescence. We used electrophysiology and molecula...