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Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
The Enzymatic Activity and Molecular Characterization of a Secreted Subtilisin-Like Protease in Microsporum gypseum and Trichophyton vanbreuseghemii
Keratinases Subtilisin-like protease Trichophyton vanbreuseghemii Microsporum gypseum
2009/12/14
Background: Subtilisin -like proteases are the group of proteases including keratinases found in dermatophytes which degraded keratin. Determination of the proteases activity of Trichophyton vanb...
Oral candidiasis in HIV+ patients under treatment with protease inhibitors
HIV Candida albicans Protease inhibitors
2009/10/16
The purpose of this work was to evaluate the influence of Protease Inhibitors (PI) on the occurrence of oral candidiasis in 111 HIV+ patients under PI therapy (Group A). The controls consisted of 56 p...
Role of bacterial protease in periodontitis.
Detection of human glandular kallikrein, hK2, as its precursor form and in complex with protease inhibitors in prostate carcinoma serum
Monoclonal antibody prostate cancer cancer diagnostic
2009/2/17
Forms of human glandular kallikrein (kK2) in prostate carcinoma serum were identified using monoclonal antibodies specific for hK2 and prohK2. Recombinant mammalian hK2, prohK2, and prostate = speci...
Interactions of proteases and protease inhibitors in Sertoli-germ cell cocultures preceding the formation of specialized Sertoli-germ cell junctions in vitro
proteases and protease inhibitors Sertoli-germ cell specialized Sertoli-germ cell
2009/2/17
The biochemical mechanism(s) by which germ cells can form specialized junctions with Sertoli cells in the seminiferous epithelium at various stages of the spermatogenic cycle is unknown. This stud...
Secretory leucocyte protease inhibitor in the male genital tract：PSA-induced proteolytic processing in human semen and tissue localization
Protease inhibitors proteolytic enzymes prostate semen seminal vesicles
2009/2/13
Secretory leucocyte protease inhibitor, SLPI, is a low-molecular-weight, acid-stable protein present in the liquid part of fresh human ejaculate but not demonstrable in the gel structure. No fragm...
Protease Activity of Allergenic Pollen of Cedar, Cypress, Juniper, Birch and Ragweed
birch cysteine protease Japanese cedar Japanese cypress juniper pollen allergy protease inhibitor proteolytic activity ragweed serine protease
2010/11/17
Clinically relevant allergenic pollens tested in the present study can release serine and/or cysteine endopeptidases. Information on the spectrum of the endopeptidase activities from these allergenic ...
Inhibition of lipolysis improves insulin sensitivity in protease inhibitor–treated HIV-infected men with fat redistribution
Lipodystrophy insulin resistance fatty acids
2016/12/29
Acute inhibition of lipolysis and reduction in fatty acid concentrations are associated with improved insulin sensitivity in patients with HIV lipodystrophy and hyperinsulinemia. Further studies are n...