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目的 明确肝显像剂99mTc-DTPA-半乳糖人血清白蛋白(99mTc-GSA)在3种不同类型肝细胞损伤小鼠模型中不同的摄取和生物分布情况。方法 3种小鼠模型分别为肝硬化、淤胆性肝损伤和肝肿瘤模型。肝硬化模型用腹腔内注射CCl4完成（每48小时腹腔注射0.4ml 10%CCl4，共48d）;淤胆性肝损伤模型以结扎胆总管72h建立;肝肿瘤模型用H22肿瘤细胞株种植肝包膜下10d建立。各模型...
Synthesis, development and preclinical comparison of two new peptide based freeze-dried kit formulation 99mTc-EDDA-Tricine-HYNIC-TOC and 99mTc-EDDA-Tricine-HYNIC-TATE for somatostatin receptor positive tumor scintigraphy
99mTc Somatostatin Tyr3-octreotide Tyr3-Octreotate HYNIC Kit formulation
2010/4/7
Somatostatin receptor (sstr) scintigraphy with [111In diethylenetriaminepentaacetic acid]-octreotide ([111In-DTPA]-OC) has became a routine diagnostic procedure in oncology. However, it suffers from s...
Evaluation of 99mTc-DTPA Renal Scanning for Localization and Shielding of the Kidneys in Patients Candidate for Abdominal Radiotherapy
Abdominal radiotherapy kidney shielding
2010/2/3
Introduction: Clinical radiation nephropathy can result in considerable morbidity and/or mortality. Renal tolerance (TD5/5) has been stated to be 20 Gy when irradiation has been delivered to both kidn...