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Reactive Oxygen Species, Mitochondria, and Endothelial Cell Death during In Vitro Simulated Dives
SCUBA DIVING OXIDATIVE STRESS REACTIVE OXYGEN SPECIES MITOCHONDRIAL MEMBRANE POTENTIAL CELL DEATH ENDOTHELIAL DYSFUNCTION
2017/4/19
Purpose: Excessive reactive oxygen species (ROS) is considered a consequence of hyperoxia and a major contributor to diving-derived vascular endothelial damage and decompression sickness. The aims of ...
Enhanced mtDNA repair and cellular survival following oxidative stress by targeting the hOGG repair enzyme to mitochondria
DNA repair DNA damage
2014/12/12
Oxidative damage to mtDNA has been implicated as a causative factor in many disease processes and in aging. We have recently discovered that different cell types vary in their capacity to repair this ...
Conditional Targeting of the DNA Repair Enzyme hOGG1 into Mitochondria
DNA repair mitochondria
2014/12/12
Oxidative damage to mitochondrial DNA (mtDNA) has been suggested to be a key factor in the etiologies of many diseases and in the normal process of aging. Although the presence of a repair system to r...