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Identification of androgen binding-protein（ABP）from testis and epididymis of the seasonal rodent, Octodon degus（Molina, 1872）
androgen binding-protein (ABP) testis seasonal rodent Octodon degus (Molina, 1872)
2009/2/23
ABP, a Sertoli cell secretory product, was identified in the seasonal rodent Octodon degus (Molina, 1872). It was shown to be present in cytosols from the testis and epididymis. It migrated with a...
Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men
MK-906 5 alpha-reductase inhibitor serum androgens androgen conjugates normal men
2009/2/23
To determine the hormonal effects of MK-906, an orally active 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates, 12 healthy men were given 10, 20, 50, and 100 mg MK-906 2 weeks a...
Age-related changes in the concentration of cytosolic androgen receptors in the epididymis, vas deferens and seminal vesicle of maturing male mice
Age-related changes cytosolic androgen receptors epididymis
2009/2/23
In this study, changes in the number of androgen binding sites that occur in cytosols of epididymis, vas deferens and seminal vesicle of mice from 10 to 90 days of age are described. Specific satura...
Effect of germ cells on vectorial secretion of androgen binding protein and transferrin by immature rat Sertoli cells in vitro
germ cells vectorial secretion androgen binding protein transferrin immature rat Sertoli cells
2009/2/23
The influence of germ cells (greater than 85% pachytene spermatocytes) on vectorial secretion of androgen binding protein (ABP) and transferrin by immature rat Sertoli cells was investigated using t...
Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations
steroid receptor-chromatin interaction inhibitors present ammonium sulfate-fractionated rat
2009/2/23
Tritiated androgen receptor complex was partially purified by ammonium sulfate precipitation at 15 to 37% saturation from rat testicular or prostatic cytosols. A greater amount of prostatic tritiate...
Evidence for age-dependent changes in Sertoli cell androgen receptor concentration
age-dependent changes Sertoli cell receptor concentration
2009/2/23
Cytosol and nuclear receptor concentrations in Sertoli cells isolated from the testes of 15-, 25-, and 35-day-old rats were measured using hydroxylapatite separation procedures. In these cells the m...
The heterogeneity of rat androgen binding protein（rABP）in the vascular compartment differs from that in the testicular tubular lumen. Further evidence for bidirectional secretion of rABP
rat ABP ABP heterogeneity
2009/2/23
Fractionation of testicular extracts and serum on a Concanavalin A-Sepharose column resolved two peaks of immunoreactive rat androgen binding protein. The rat androgen binding protein in the first pea...
Concentrations of free testosterone, total testosterone, and androgen binding protein in the peripheral serum of male rats during sexual maturation
free testosterone total testosterone androgen binding protein peripheral serum male rats
2009/2/23
To investigate the relationship between free testosterone and sexual maturation in the male rat, animals were decapitated every 5 days from 25 through 75 days of life. Serum was assayed for androgen...
Whole cell and nuclear androgen uptake in skin fibroblasts from infertile men
Whole cell nuclear androgen uptake skin fibroblasts infertile men
2009/2/23
In order to reexamine the hypothesis that a high percentage of infertile men with oligo/azoospermia have androgen resistance due to androgen receptor abnormalities, both whole cell and nuclear uptak...
Androgen receptor levels and androgen contents in the prostate lobes of intact and testosterone-treated Noble rats
Androgen receptor levels androgen contents prostate lobes testosterone-treated Noble rats
2009/2/23
Plasma testosterone (T) levels were correlated with androgen receptors, tissue content of T, and 5 alpha-dihydrotestosterone (DHT) in the three anatomically-discrete prostate lobes of intact and cas...
The effects of the indazole carboxylic acid derivative, tolnidamine, on testicular function：I. Early changes in androgen binding protein secretion in the rat
tolnidamine rABP LH FSH testosterone
2009/2/20
The indazole carboxylic acid derivative, tolnidamine, has marked antispermatogenic activity in several animal species. In this study, we assessed the effect of tolnidamine on rat Sertoli cell functi...
Secretion of androgen binding protein by Sertoli cells is influenced by contact with germ cells
androgen binding protein Sertoli cells germ cells
2009/2/20
Sertoli cells were cultured alone or with germ cells to evaluate the effect of the association with germ cells on the secretory activity of Sertoli cells. Secretion of androgen-binding protein, whic...
Fetal irradiation increases androgen production by dispersed leydig cells of the rat
seminiferous tubule damage fetal irradiation
2009/2/20
Damage to the seminiferous epithelium of the rat has been shown to decrease the concentration of serum testosterone. In these animals, compared to controls, the structure of the Leydig cells sugge...
The role of endogenous opioid peptides in the control of androgen levels in the male nonhuman primate
morphine endorphin enkephalin naloxone
2009/2/20
Plasma androgen levels studied following the injection of the opioid agonists morphine sulfate (0.5-1.0 mg/kg), beta-endorphin (10-20 mg/kg), and [D-Ala2, D-Leu5]-enkephalin (DADLE; 5-20 microgram...
Fibroblast androgen receptors in patients with genitourinary anomalies
Fibroblast androgen receptors patients genitourinary anomalies
2009/2/20
The etiology of certain disorders of sexual differentiation is unclear. The authors have examined the hypothesis that hypospadias and other disorders compatible with a defect in androgen action, suc...