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The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial designed to determine the effects of a high-fiber (4.30 g/MJ), high-fruit-and-vegetable (0.84 servings/MJ), low-fat (20%...
Polyunsaturated fatty acids in milk are derived from direct intestinal absorption, endogenous synthesis, or maternal body stores. Arachidonic acid (AA) intake is frequently low in undernourished wo...
Adjustments of carbohydrate intake and oxidation occur in both normal-weight and overweight individuals. Nevertheless, the contribution of carbohydrates to the accumulation of fat through either re...
The recent paper by Dreon et al (1) reported that a very-lowfat diet is not associated with improved lipoprotein profiles in men. The dietary nutrient data presented in their Table 1 show that at t...
Current dietary guidelines emphasize reductions in dietary fat, particularly saturated fat, for the hygienic control of plasma lipoproteins. This recommendation is based on abundant scientific evid...
We found previously that men with a predominance of large LDL particles (phenotype A) consuming highfat diets (40–46% fat) show less lipoprotein benefits of low-fat diets (20–24% fat) than do men w...
Full-fat sitostanol ester–containing margarine reduces serum total and LDL cholesterol, but the effect of plant stanol ester–containing margarine as part of a low-fat, low-cholesterol diet has not ...
Background: Systems to calculate metabolizable energy (ME) in foods and diets are often based on Atwater factors. The accuracy of these factors with low-fat diets high in fiber is unknown when food in...
Background:Dietary fat has a lower thermogenic effect than does carbohydrate. A moderate-fat diet, high in monounsaturated fatty acids (MUFA diet), may decrease energy expenditure (EE) and thereby ind...
Background: Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs).Objective: We tested wh...
Metabolic rate is known to rise above basal levels after eating, especially following protein consumption. Yet, this postprandial rise in metabolism appears to vary among individuals. This study exami...
Recent evidence suggests that a low carbohydrate (LC) diet may be equally or more effective for short-term weight loss than a traditional low fat (LF) diet; however, less is known about how they compa...
Hypertriglyceridemia is associated with increased risk of cardiovascular disease. Until recently, the importance of hepatic de novo lipogenesis (DNL) in contributing to hypertriglyceridemia was diffic...
Background: Overweight individuals with metabolic syndrome are at increased risk of type 2 diabetes and coronary vascular disease. Weight gain and features of the syndrome may be ameliorated by d...
Background: Cholesterol ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to apolipoprotein (apo) B–containing lipoproteins. The possible atherogenic role of this p...

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