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近日，我院代谢性疾病研究团队张君教授与兵团特聘专家常永生教授合作，在国际糖尿病研究领域顶级期刊《Diabetes》上发表论文《Cold-Inducible Klf9 Regulates Thermogenesis of Brown and Beige Fat》(IF: 7.72)。寻找促进棕色和米色脂肪分化并激活其功能的关键因子，将为治疗肥胖症提供药物作用的靶点，该论文为解决上述关键问题提供了理论...
A systematic review and meta-analysis of nutrition therapy compared with dietary advice in patients with type 2 diabetes
dietary advice individualized nutrition therapy meta-analysis review type 2 diabetes
2018/11/21
Background: Despite recommendations, many patients with type 2 diabetes receive dietary advice from nurses or doctors instead of individualized nutrition therapy (INT) that is provided by a dietitian.
Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes
trimethylamine-N-oxide type 2 diabetes flavin monooxygenase 3 polymorphisms nutrition metabolite
2018/11/19
Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes
trimethylamine-N-oxide type 2 diabetes flavin monooxygenase 3 polymorphisms, nutrition metabolite
2018/11/16
Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
Maternal protein intake in pregnancy and offspring metabolic health at age 9–16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls
pregnancy gestational diabetes mellitus protein insulin body composition
2018/11/15
Background: Recent years have seen strong tendencies toward high-protein diets. However, the implications of higher protein intake, especially during developmentally sensitive periods, are poorly unde...
Effect of carbohydrate restriction in the first meal after an overnight fast on glycemic control in people with type 2 diabetes: a randomized trial
carbohydrate continuous glucose monitoring glucose postprandial type 2 diabetes
2018/12/18
Background: People with type 2 diabetes are advised to consume an even meal distribution of carbohydrate. Whether this distribution is optimal is unknown.
Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies
animal protein dietary protein meta-analysis plant protein prospective study type 2 diabetes
2018/12/18
Background: Reported associations between protein intake from different sources and type 2 diabetes (T2D) have been inconsistent.
Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study
calcium-sensing receptor polymorphism cohort study diabetes mellitus race serum calcium
2018/12/14
Background: Elevated serum calcium has been associated with a variety of metabolic abnormalities and may be associated with a greater risk of diabetes.
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver iver enzymes GDM fatty liver ransaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver liver enzymes GDM fatty liver transaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
Mediterranean diet coronary artery disease olive oil phenolics proteomic biomarkers
2018/12/19
Background: Olive oil (OO) consumption is associated with cardiovascular disease prevention because of both its oleic acid and phenolic contents. The capacity of OO phenolics to protect against low-de...
Protein Kinase C–Dependent Increase in Reactive Oxygen Species Production in Vascular Tissues of Diabetes:
Protein Kinase C–Dependent Increase Production
2014/3/31
saturated nonesterified fatty acids (NEFA) can stimulate de novo DAG synthesis and PKC activity in cultured aortic EC and smooth muscle cells,Antioxidative Agents Targeting the Mechanism of NAD(P)H Ox...