搜索结果: 1-8 共查到“生物工程 mutations”相关记录8条 . 查询时间(0.029 秒)
Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. However, for the vast majority of those mutations, researchers are unsure of how they contribute to...
Gene editing, or purposefully changing a gene’s DNA sequence, is a powerful tool for studying how mutations cause disease, and for making changes in an individual’s DNA for therapeutic purposes. A nov...
Model expands landscape for signaling protein mutations
Model expands landscape signaling protein
2016/11/4
Protein pairs that control stimulus response in bacteria maintain a sensitive balance between interaction specificity and promiscuity, according to Rice University scientists.A computational model dev...
Missense mutations in exon 2 of the porcine leptin receptor gene and their associations with litter size and body weight
LEPR SNPs pigs
2015/6/8
Leptin receptor (LEPR) gene is regarded as a “candidate-gene” of production traits. The aims of this study were to detect polymorphisms of exon 2 within LEPR gene and to investigate their associations...
Molecular and functional analysis of mutations that result in insecticide resistance in Colorado potato beetle
Gene mutations pain and the potato beetle biological molecules the rate constant
2014/12/11
The functional aspects of specific mutations, R30K, S291G, and I392T, found associated with AChE gene of OP- and carbamate-resistant Colorado potato beetle (CPB) were determined using recombinant AChE...
Classification of gene mutations in a children's cancer may point to improved treatments（图）
gene cancer
2014/12/1
Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibito...
缺血性脑卒中患者同型半胱氨酸代谢相关酶基因突变的研究 Genetic Mutations of Homocysteine Metabolism Related Enzymes in Patients with Ischemic Stroke
缺血性脑卒中 胱硫醚—β—合成酶 亚甲基四氢叶酸还原酶 基因突变 基因频率
2008/1/8
摘要
为研究同型半胱氨酸代谢相关酶亚甲基四氢叶酸还原酶(MTHFR)基因C677T和胱硫醚-β-合成酶(CBS)基因T833C位碱基突变与缺血性脑卒中的关系，对74例缺血性脑卒中患者和83例健康对照者, 采用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)技术检测MTHFR基因 C677T基因型, 用扩增阻滞突变体系法(ARMS)检测CBS基因T833C突变。实验检出患者组MTHFR基因T...
肝癌组织中线粒体DNA D-Loop区碱基变异与ROS水平Mutations in the D-Loop Region of Mitochondrial DNA and the ROS Level in the Tissue of Hepatocellular Carcinoma
线粒体DNA D-Loop 原发性肝癌 突变 活性氧类物质
2008/1/6
摘要
为了探讨ROS水平与突变的关系，对原发性肝癌线粒体DNA区的突变情况进行研究，同时对原发性肝癌患者组织细胞内ROS进行测定。选择20例原发性肝癌组织及其邻近的癌旁组织，用PCR方法将线粒体DNA D-Loop扩增后测序。组织内ROS的水平采用流式细胞技术测定。结果表明在20对原发性肝癌组织中存在8对mtDNA突变，突变率为40%,共发现突变位点53个，包括2个插入，11个缺失...