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分析同时伴有2种及2种以上的荧光原位杂交(FISH)结果异常的多发性骨髓瘤(MM)患者的预后情况,筛选预后较差的MM者。 方法:共计纳入2011年7月至2017年2月期间767例在长征医院就诊的初诊MM患者,所有患者初诊时均进行FISH检测,所检测的FISH异常包括IgH易位、t(4;14)、t(11;14)、t(14;16)、17p-、1q扩增、-13/13q-,分析所有FISH异常对预后的影响...
观察脱落细胞学检查(EC)、荧光原位杂交技术(FISH)及膀胱肿瘤抗原(BTA)3种方法联合诊断肾盂癌的临床价值。方法回顾性分析保定市第二医院泌尿外科120例疑似肾盂癌患者临床病历资料,记录所有患者EC、FISH及BTA结果,以病理活检结果为金标准,分析单一或联合采用3种检查方法诊断肾盂癌的准确性,并绘制受试者工作曲线(ROC),比较单一或联合采用3种检查方法的价值。
EML4-ALK基因重排(即ALK阳性)肺癌是非小细胞肺癌的最新分子亚型。临床研究表明,ALK阳性的晚期NSCLC患者应用针对抗ALK靶向治疗的小分子药物克唑替尼(Crizotinib)在无进展生存期(PFS)和客观缓解率(ORR)上显著优于常规化疗。因此ALK融合基因检测对临床实践尤为重要。而目前常用于检测ALK突变的方法包括荧光原位杂交(FISH)、全自动免疫组化(Ventana ALK D5...
Beginning in the late 1960s, landmark epidemiologic observations made in fish-eating populations from Greenland, Canada, Alaska, China, and Japan suggested an inverse association between the consumpti...
Beginning in the late 1960s, landmark epidemiologic observations made in fish-eating populations from Greenland, Canada, Alaska, China, and Japan suggested an inverse association between the consumpti...
Background: Parenteral fish-oil (FO) therapy is a safe and effective treatment for intestinal failure–associated liver disease (IFALD). Patients whose cholestasis does not resolve with FO may progress...
The steps in the development of important medical discoveries rest first on intuition and then on associations of a certain factor with a disease, followed by scientifically designed experiments. T...
Obesity in hypertensive patients is associated with dyslipidemia and insulin resistance, both of which are improved by weight control. n23 Fatty acids have diverse effects on mechanisms underlying ...
Although several studies have investigated the relation between fish consumption and the risk of cardiovascular diseases, less attention has been paid to the relation between fish consumption and c...
Histamine food poisoning is found to be associated with consumption of scombroid fish containing unusually high levels of histamine. Fish belonging to non-scombroid group may also cause histamine pois...
Omega-3 fatty acids (n-3) has shown to improve neuromotor function. This study examined the effects of docosahexaenoic acid (DHA) on complex reaction time, precision and efficiency, in female elite so...
Background: Fish is a rich source of n–3 polyunsaturated fatty acids (PUFAs) but also contains the neurotoxicant methyl mercury (MeHg). PUFAs may modify the relation between prenatal MeHg exposure and...
Background: Despite mechanistic data that linked fish and omega-3 (n–3) PUFAs with lower risk of chronic obstructive pulmonary disease (COPD), epidemiologic data remain scarce. Fish and n–3 PUFAs are ...
Background: Despite mechanistic data that linked fish and omega-3 (n–3) PUFAs with lower risk of chronic obstructive pulmonary disease (COPD), epidemiologic data remain scarce. Fish and n–3 PUFAs are ...
In the aquatic environment, suction feeding is far more common than biting as a way to capture prey. A new study shows that the evolution of biting behavior in eels led to a remarkable diversification...

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