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体外分析环磷酸鸟苷是否(cGMP)通过cGMP依赖性蛋白激酶(cGK)调控人纤溶酶原激活物抑制剂2(PAI-2)基因启动子活性,阐明PAI-2基因表达的分子调控机制。方法:构建cGK的真核过表达载体及其小干扰RNA(siRNA)敲减体系,以及PAI-2基因启动子缺失突变序列双萤光素酶报告载体,瞬时转染人肺动脉平滑肌细胞(HPASMCs),在可溶性鸟苷酸环化酶(sGC)特异性刺激剂BAY 41-22...
Bees make wax (lipid) from honey (carbohydrate). Pigs fatten on a grain diet. Indeed, all organisms, from bacteria to mammals, have the enzymes of de novo lipogenesis. The physiologic function of d...
It was recently shown that antiendomysial antibodies (EMAs), which are highly sensitive and specific for celiac disease, are produced by intestinal mucosa. Furthermore, EMAs were detected previousl...
The title and conclusions of the article, “Bioavailability of iron glycine as a fortificant in infant foods,” by Fox et al (1) are not supported by the data presented. Their data show that the abso...
Tocotrienols, lipid-soluble antioxidants with vitamin E activity, have been reported to lower LDL-cholesterol concentrations and platelet aggregation in men, but results are contradictory.
Introduction: Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by mucocutaneous perioral pigmentation, gastrointestinal hamartomatous polyposis, and an increased risk of malignancy. Famil...
探讨白藜芦醇(RES)对去卵巢大鼠腰椎骨密度及一氧化氮(NO)和一氧化氮合酶(NOS)影响。方法 48只SD大鼠随机分为6组,分别为假手术组、去卵巢组、己烯雌酚(0.03 mg/kg)、RES 5、15、45 mg/kg组,处理90 d后,观察各组大鼠腰椎骨密度、血清中NO含量和NOS浓度变化。结果 与假手术组比较,去卵巢组大鼠第4、5、6腰椎骨密度[分别为(0.141 4±0.001 1)、(0...
The aim of this study was to compare the speed and the agility between Brazilian soccer players and non-players, regarding maturity status in adolescents 11-15 years old. Forty and two soccer players ...
In male high-level long-distance runners over 10,000 m, a positive association between both the front thigh and medial calf skin-fold thickness and running performance has been demonstrated. It is ass...
Background: The optimal source and amount of dietary carbohydrate for managing type 2 diabetes (T2DM) are unknown. Objective: We aimed to compare the effects of altering the glycemic index or the ...
Background: In recent prospective studies, higher homocysteine concentrations were shown to be a risk factor for osteoporotic fractures in older persons. Supplements containing folate and vitamins B-1...
Background: Preventing illness and improving growth in the first 6 mo of life is critical to reducing infant mortality. Zinc given for 14 d at the start of diarrhea has been shown to decrease the inci...
1 February 2007,Of the one million Americans with HIV, some 250,000 do not know that they are infected. If they do not know, they will not seek treatment and they are more likely to infect others. The...
Reductions in iodine and zinc deficiencies and improvements in hemoglobin were achieved from a micronutrient-fortified seasoning powder consumed in school lunches by children in northeast Thailand.
In study 1, there were no significant within-pair differences in unadjusted BMD or BMD adjusted for age, height, and fat mass at the lumbar spine or total-hip or in total-body bone mineral content (BM...

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