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近年来,抗逆转录病毒疗法(ART)在抑制HIV复制方面取得了显著进展,显著延长了艾滋病患者的寿命,但该疗法同时也带来了严重的副作用,并导致大量耐药病例的出现。CD4作为HIV进入宿主细胞的主要受体,一直是HIV药物研发的重点靶点。然而,目前唯一的CD4抗体药物在抑制HIV病毒的广谱性和效率上仍存在不足,长期应用会导致耐药性的产生。因此,探索更有效、更广谱的中和抗体成为当务之急。
2021年,7月16日,《信号转导与靶向治疗》(Signal Transduction and Targeted Therapy)在线发表了中国科学院分子细胞科学卓越创新中心研究员陈剑峰课题组和中科院大连化学物理研究所研究员李国辉、副研究员张跃斌团队合作完成的最新研究成果——Distinct chemokines selectively induce HIV-1 gp120-integrin α4...
Nearly 37 million people worldwide are living with HIV. When the virus destroys so many immune cells that the body can’t fight off infection, AIDS will develop. The disease took the lives of more than...
Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been p...
Bone studies of HIV-infected children using dual X-ray absorptiometry (DXA) suggest bone mineral density (BMD) abnormalities. Pediatric studies are often performed using DXA instead of computed tomogr...
Objectives: The aims of this study was to analyze the immuno-virologic response after optimised background antiretroviral therapy (OBT) associated to new active antiretroviral treatment (ART) in HIV-1...
Background: In Uganda's HIV prevention strategy religious institutions are encouraged to deliver HIV prevention messages to the general public and to integrate HIV prevention into faith-based activiti...
Thyroid abnormalities have been reported in persons with HIV infection, although data have been inconsistent with respect to its frequency and association with specific medications. The purpose of thi...
Background: Since 2001, anti-retroviral therapy (ART) has been provided to over 75,000 HIV-infected patients at the USAID-Academic Model Providing Access to Healthcare (AMPATH) Partnership in western ...
Lack of integration and coordination between HIV prevention programmes and developmental programmes explain why many countries have not been able to halt the epidemic, and others still have unacceptab...
Socially disadvantaged individuals with HIV experience unacceptably high rates of AIDS and death. The authors developed an adversity index to quantify the impact of demographic and psychosocial factor...
Background: The failure to monitor and link patients from HIV testing to HIV care and retain them in care until they are eligible for ART is a major barrier to early ART initiation. This study evaluat...
South Africa has seen an increasing population of children and adolescents accessing antiretroviral treatment (ART) in the past seven years. Many of these children are at the age when they should know...
The main purpose of this study is to find the awareness level as well as the determinants of awareness on HIV/AIDS among the garments workers in Dhaka City, Bangladesh. To do so, 200 garments workers ...
Background: Patients coinfected with HBV, HDV, HCV and HIV are usually excluded from clinical trials. Data on pegylated interferon treatment in this setting are limited, with predictive factors for HD...

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